We conduct research along several lines, all of which share a common
foundation in Organic Chemistry (synthesis) and the use of light (fluorescence,
photo-irradiations). We design and synthesize
molecules and polymers aimed at addressing biomedical challenges, ranging from
the fluorescence detection of reactive species within cells (associated with
cancer and other pathologies) to therapeutic strategies for eliminating cancer
cells and microbial pathogens (photodynamic therapy, PDT). More details about
our activities can be found below.
If you are interested in joining us as a PhD student or postdoctoral
researcher, or in establishing a collaboration, please don’t hesitate to get in
touch.
Our
current projects are focused on the preparation of structures capable of
reaching the mitochondria on living cells, specially cancerous ones, and be
able to detect them by confocal microscopy. Once in the mitochondria, a double
goal is pursued: detecting species of biochemical interest (fluorescence)
and/or eliminating undesired cells using light (mitochondrial PDT).
In
relation to this topic, we also develop small-molecule photosensitizers as
photo-antimicrobials, with a particular focus on drug-resistant strains
responsible for hospital-acquired infections.
Another
line of interest is the preparation of polymeric materials with
photo-antimicrobial properties, in order to prevent
contamination by bacterial and fungal pathogens.
Numerous
BSc, MSc, and PhD students have carried out high-quality research in our
facilities. Our work is also strongly collaborative, and we have established
strong partnerships with research groups both nationally and internationally.
Explore
here a selection representative publications from our
group.
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